Chronic Heart Failure (CHF) is a progressive disease arising when the heart is unable to fill with (diastolic failure) and/or pump (systolic failure) blood sufficiently. Current diagnostic tools, beyond ultrasound, are unable to differentiate systolic and diastolic heart failure, but different management strategies are required for each. The PROOF Centre is working to develop blood biomarker tests to distinguish diastolic from systolic heart failure, to guide clinicians in selecting the most appropriate therapy for individual patients regardless of their remoteness geographically.
Acute Heart Failure (AHF) is a life-threatening condition characterized by inadequate cardiac output and blood pressure instability. AHF patients may develop CHF, or progress to require ventricular assist devices /cardiac transplantation, or death. Our objective is to discover blood biomarkers of acute heart failure to better manage patients facing the possibility of a ventricular assist device.
Read more about our Heart Failure Programs here.